Blaster Master 2 (BM2) was released in 1993, two years after Blaster Master Boy. The game artwork and engine was developed by the now defunct Software Creations (a.k.a. Creations) under license from Sunsoft, and the series had now moved on to the Genesis, Sega's intrepid 16-bit machine. Regional market releases for BM2 included those of Europe, Asia-Pacific, and the U.S.

Under the development team of Creations and the marketing team at Sunsoft, several things were altered in the new BM2 game, such as the name of the vehicle changed to "S.O.P.H.I.A.", and the gameplay was expanded significantly.

The platform-jumping characteristics that made the original NES game so popular among fans were preserved, while other viewpoints provided an additional level of gameplay unique to BM2 alone. There were now three ways to play: sidescroll view (S.O.P.H.I.A. and Jason), top view (S.O.P.H.I.A.), and Jason running through rooms (with a large view, and a small view with Jason running through certain parts of the stages). In the sidescroll view, players battled through levels just like in BM, except in 16-bit graphics. Jason could get powerups such as homing missile, three-way missiles, bubble shield, and lightning spread. In top view, S.O.P.H.I.A. could not use upgrades, but instead could rotate the turret 360 degrees while the player ran through obstacles and gunfire, a la Vindicators.

During the course of the game, Jason could enter several rooms, one of which may contain a mini-boss (such as a giant bee or worm) that he must fight in order to gain a powerup or key that will let him enter the next stage.

Sometimes these mini-bosses will give Jason or S.O.P.H.I.A. a powerup that enhances their abilities. For example Jason can get a jetpack, or missile launcher. S.O.P.H.I.A. can get a hover module, or a drill that can break through stone.

In all, BM2 provided a 16-bit "arcade"-type addition to the Blaster Master saga, with the original elements brought in and enhanced for the newest home consoles available at the time.